Botanical: Prunus serotina
Parts Used: Bark (from both root and branches)
Energetics: bitter, sedative
Properties: anti-inflammatory, antispasmodic, astringent, circulatory tonic, cough suppressant, digestive bitter and tonic, digestive tonic, expectorant, sedative
Used for: accumulation of hardened mucus, asthma, bronchitis, dyspepsia, diarrhea, dysentery, edema, jaundice
Common Names: American Cherry, Black Cherry, Mountain Black Cherry, Rum Cherry, Wild Black Cherry
Herbalists value the wild cherry for its inner bark which is a main ingredient in wild cherry cough syrup. A native of North America, it grows from Canada even down into Florida in the United States. It is a large, deciduous tree with a rough, reddish-brown bark and lustrous, dark green, oval, serrate leaves with pointy tips, and it bears small, delicate white flowers that bloom in April.
The flowers are followed by one-seeded, purplish-red fruits that ripen in late summer and early autumn. The tree, which may reach a height of one hundred feet, can be found wild in moist woodlands and thickets, by riverbanks, or cultivated in well-drained, neutral-to-alkaline soil in sun, and it is prone to frost damage in a cold spring.
Wild cherry trees are hardy, fast growing, and long-lived. Fruit is dark purple, sweet and edible.
Culinary Uses for Wild Cherry
The wood of Prunus spp is also used for smoking foods. The flavor cherry wood produces is light and sweet. It is delicate and not overpowering. This makes cherry a good wood mix with others such as apple, oak or hickory.
The Apaches ground the entire fruit, pit and all, and pressed the meal into small, hard, dark biscuit-like cakes, which were stored and reconstituted on the trail by boiling, thus both softening and driving off the readily vaporizing prussic acid with heat. 
Like apples, pears, bitter almond, and peach, the seeds of wild cherries contain cyanogenic glycosides, compounds that can be converted into cyanide, such as amygdalin.  These compounds release hydrogen cyanide when the seed is ground, which releases enzymes that break down the compounds. These enzymes include amygdalin beta-glucosidase, prunasin beta-glucosidase and mandelonitrile lyase.  This is what can trip people up… the flesh of cherries also contains these compounds, it does not contain the enzymes needed to produce cyanide, so the flesh is safe to eat.
Matthew Wood says it so much better, so I will just quote him here…
The classic symptoms of inflammation and fever (heat, redness, swelling, tenderness, and rapid heartbeat) for which wild cherry has long been used additionally contains cyanogens, which break down into hydrocyanic acid. This stops the Krebs cycle, which is the body’s mechanism for producing energy. Thus cyanogens cut down heat production at the cellular level. This is why too much cyanide can kill a person. Fortunately, the amount of cyanide in a small does of wild cherry bark is only enough to cool. The cyanogens and flavonoids work together to sedate and cool the organism. They are most commonly found together in members of the rose family. 
The Prunus serotina is in the same Rosaceae family as Apples, Plums, Peaches, Nectarines, Apricots, Almonds, Raspberries and Roses. What do plants in this family have in common? They are all wonderful herbal companions!
The inner bark of the wild cherry tree Prunus serotina is a very old and revered herbal remedy used by both indigenous Native Americans tribes made use of the wild cherry bark for healing, including the Huron, Iroquois, Malecite, Mohawk, Potawatomi, Chippewa, and Ojibwa. Most commonly used by these tribes for coughs and colds, a digestive aid, as an internal pain reliever, and as a disinfectant and eye wash. 
The Cherokees utilized the bark for pain relief during labor while the Mohegans saw it as a remedy for various illnesses including dysentery.
Using Wild Cherry for Wellness
Wild cherry bark’s use for reducing the symptoms of respiratory distress is without equal in the herbal kingdom. It continues to be included in the USP (The Pharmacopoeia of the United States) and has remained since 1820, as an anti-tussive and sedative.
Wild cherry bark preparations for cough are an honest to goodness antitussive. While it is important to let a productive cough do it’s thing, there is a time to sleep. Wild cherry cough syrup is best used for an irritating, spastic cough that is NOT productive. It is also beneficial for that time after a bout with a cold/flu is on the mend, but when you go outside or take in breath too quickly and it brings on a coughing fit. It’s like there is nothing to really cough up and still you cough. (unproductive cough) Wild cherry is an herb that helps reduce spasm and ease breathing.
It is also a good anti-inflammatory, this is why it helps in conditions that include allergies.
John Uri Lloyd declared it the most commonly used domestic remedy in the late nineteenth century. It was primarily used as a coolant in fever and irritative coughs. Wild Cherry possesses flavonoids, bitter cyanogens, tannins, a bit of mucilage, resins, and volatile oils. 
Wild Cherry bark can also be beneficial in aiding the symptoms of herpes and shingles. Herpes and shingles are most always treated by anti-inflammatory and cooling anti-viral herbs (often combined with Wild Cherry) like Lemon Balm, Linden, or St. John’s Wort.
Its bark is collected, not during the early spring, as is usual with most barks, but during the summer or late fall when the cyanogenic compounds are reportedly lower in the bark. Richard Mabey  explains a bit about how it works in the body…
Wild cherry bark is an important cough remedy. Once ingested, the cyanogenic glycosides are hydrolized to glucose, bensaldehyde, and hydrocyanic acid, otherwise known as prussic acid. Prussic acid is excreted rapidly , largely via the lungs where it at first increases the respiration and then sedates the sensory nerves which provoke the cough reflex. Although prussic acid is highly poisonous, if wild cherry bark is used in medicinal doses, the low prussic acid content (0.07-0.16%) ensures that the remedy is quite safe. Both the cyanogenic glycosides and volatile oil in wild cherry bark improve the digestion.
In “The Herbalist’s Way” Nancy & Michael Phillips say…
Combination menstruums are useful for extracting certain types of constituents. For plants high in both tannins and volatile oils, like the bark of wild cherry we need to use some glycerin along with the alcohol to keep the tannins from precipitating out the volatile oils. This a 1:5 tincture of the dry bark is recommended to be made with 60 percent alcohol, 10 percent glycerin, and 30 percent water. Vinegar used in combination with alcohol assists in the extraction of alkaloidal (base_ substances from certain herbs. The acid in the vinegar causes a chemical reaction wherby the alkaloids are turned in to alkaloidal salts, which in turn become available in solution. 
Dosage: cold infusion: 4-6 oz. 2-3 times daily; DPT (40% alcohol, 20% glycerin): 60-90 drops 2-3 times daily; fluid extract: 20-40 drops 2-3 times daily; Syrup: 1-2 teaspoons 1-3 times daily
* Dosage by [Charles W. Kane]
Dosage by Stephen Bruhner – Tincture, late summer or fall bark, 1:5, 60% alcohol, 10% glycerine 30-90 drops up to 4x daily. 
Theoretically large amounts may cause bronchial and cardiovascular suppression; none known with normal dosage. Please see the reference [#7] to truly clarify.
- Wild cherry bark is generally regarded as safe to take as long as you do not overdo your dose.
- Fresh wild cherry leaves are toxic to animals, particularly when wilted for it is then that they contain the largest amount of cyanide. The berries are not poisonous but eating large amounts at one time is not advised.
- Pregnant women, nursing mothers and children under the age of two should avoid using wild cherry bark.
- Erichsen-Brown, Charlotte “Medicinal and Other Uses of North American Plants” A historical survey with special reference to the eastern Indian tribes. Dover, 1979. Print
- Swain E, Poulton JE (October 1994). “Utilization of Amygdalin during Seedling Development of Prunus serotina”. Plant Physiology. 106 (2): 437–445. :10.1104/pp.106.2.437. 159548. 12232341
- Yemm RS, Poulton JE (June 1986). “Isolation and characterization of multiple forms of mandelonitrile lyase from mature black cherry (Prunus serotina Ehrh.) seeds”. Archives of Biochemistry and Biophysics. 247 (2): 440–5. :10.1016/0003-9861(86)90604-1. 3717954
- Wood, Matthew. The Earthwise Herbal: A Complete Guide to New World Medicinal Plants. North Atlantic, 2009. Print.
- Mabey, Richard, The New Age Herbalist: How to use herbs for healing, nutrition, body care, and relaxation Gaia Books Ltd., London, 1988. Print.
- Nancy & Michael Phillips, The Herbalist’s Way: The Art 7amp; Practice of Healing with Plant Medicines. Chelsea Green Publishing, 2005. Print
- Kane, Charles W. herbal medicine: trends and traditions, A Comprehensive Sourcebook on the Preparation and Use of Medicinal Plants. Lincoln Town Press, 2009 Print.
Field guide and poisonous plant “experts” love to talk of Wild cherry – seeds and leaves – due to its glycoside content as a DEADLY poison. Take it with a grain of salt: hydrogen cyanide is to Wild cherry what cocaine is to Coca leaf. It is a miniscule fraction.
- Buhner, Stephen Harrod, “Herbal Antibiotics” Natural Alternatives for Treating Drug Resistant Bacteria. Storey Publishing, 2012. Print
- Anti-proliferative effect of horehound leaf and wild cherry bark extracts on human colorectal cancer cells.
- Comparison of kinetic and molecular properties of two forms of amygdalin hydrolase from black cherry (Prunus serotina Ehrh.) seeds.
- Development of the Potential for Cyanogenesis in Maturing Black Cherry (Prunus serotina Ehrh.) Fruits.
- Evaluation of the hydroxynitrile lyase activity in cell cultures of capulin (Prunus serotina).
- Extracts of Canadian first nations medicinal plants, used as natural products, inhibit neisseria gonorrhoeae isolates with different antibiotic resistance profiles.
- Flavonoids from Prunus serotina Ehrh.
- High-performance liquid chromatographic identification of flavonoid monoglycosides from Prunus serotina ehrh.
- Identification of monomeric and polymeric 5,7,3’4′-tetrahydroxyflavan-3,4-diol from tannin extract of wild cherry bark USP, Prunus serotina Erhart, family Rosaceae.
- Immunocytochemical Localization of Mandelonitrile Lyase in Mature Black Cherry (Prunus serotina Ehrh.) Seeds.
- Immunocytochemical Localization of Prunasin Hydrolase and Mandelonitrile Lyase in Stems and Leaves of Prunus serotina.
- Investigation of the microheterogeneity and aglycone specificity-conferring residues of black cherry prunasin hydrolases.
- Isolation and characterization of multiple forms of mandelonitrile lyase from mature black cherry (Prunus serotina Ehrh.) seeds.
- Isolation and characterization of multiple forms of prunasin hydrolase from black cherry (Prunus serotina Ehrh.) seeds.
- Localization and catabolism of cyanogenic glycosides.
- Multiple introductions boosted genetic diversity in the invasive range of black cherry (Prunus serotina; Rosaceae).
- Nonsteroidal anti-inflammatory drug activated gene-1 (NAG-1) modulators from natural products as anti-cancer agents.
- Nutraceutical value of black cherry Prunus serotina Ehrh. fruits: antioxidant and antihypertensive properties.
- The occurrence and seasonal distribution of C50-C60-polyprenols and of C100-and similar long-chain polyprenols in leaves of plants.
- Prunus serotina Amygdalin Hydrolase and Prunasin Hydrolase : Purification, N-Terminal Sequencing, and Antibody Production.
- Prunus spp. intoxication in ruminants: a case in a goat and diagnosis by identification of leaf fragments in rumen contents.
- Quantitative analysis of amygdalin and prunasin in Prunus serotina Ehrh. using (1) H-NMR spectroscopy.
- A simple and highly sensitive spectrophotometric method for the determination of cyanide in equine blood.
- Simultaneous quantification by HPLC of the phenolic compounds for the crude drug of Prunus serotina subsp. capuli.
- Temporal and spatial expression of amygdalin hydrolase and (R)-(+)-mandelonitrile lyase in black cherry seeds.
- Tissue and Subcellular Localization of Enzymes Catabolizing (R)-Amygdalin in Mature Prunus serotina Seeds.
- Tissue Level Compartmentation of (R)-Amygdalin and Amygdalin Hydrolase Prevents Large-Scale Cyanogenesis in Undamaged Prunus Seeds.
- [Toxic and less toxic plants. 39. Prunus padus, Prunus serotina].
- Vasoactive and antioxidant activities of plants used in Mexican traditional medicine for the treatment of cardiovascular diseases.